Chromatography Standards
Medchemexpress LLC Flunixin (meglumine) | 42461-84-7 | 99.65% | 1 ML
Flunixin meglumine is a cyclooxygenase (COX) inhibitor exhibiting anti-inflammatory effects. It inhibits lipopolysaccharide-induced inducible nitric oxide synthase (iNOS) activity and nuclear factor kappa B (NfκB) activation in RAW 264.7 murine macrophages. In vivo, it inhibits carrageenan-induced exudate PGE2 and serum TXB2 generation.
Sigma Aldrich Fine Chemicals Biosciences Tyloxapol United States Pharmacopeia (USP) Reference Standard | 25301-02-4 | MFCD00149002 | 3X200MG
Tyloxapol United States Pharmacopeia (USP) Reference Standard | 25301-02-4 | MFCD00149002 | 3X200MG
Apexbio Technology LLC Atovaquone(Synonyms: Mepron, Wellvone, 566C80, BW 566C, Atavaquone, Hydroxy-1,4-naphthoquinone derivative), 50mg, CAS: 95233-18-4.
Atovaquone (CAS 95233-18-4) is a hydroxynaphthoquinone compound employed in biomedical research primarily due to its inhibitory action against mitochondrial electron transport in pathogenic microorganisms Specifically it targets cytochrome bc1 complex (complex III) disrupting mitochondrial respiration and consequently impairing pyrimidine biosynthesis and replication in parasites This mechanism underlies its research utility in studying parasite metabolism and antiprotozoal therapeutics notably concerning Pneumocystis jirovecii pneumonia toxoplasmosis malaria and babesiosis
Cayman Chemical Temozolomide, Purity: ≥98%, CAS: 85622-93-1, 25 mg
A prodrug form of MTIC; selectively cytotoxic to MGMT-deficient U87 and D54 cells over MGMT-expressing T98G and U3054MG cells (IC50s = 51, 12, 660, and 370 µM, respectively); increases survival in a Br23c glioblastoma orthotopic mouse xenograft model at 15 mg/kg; decreases tumor volume and increases the number of tumor-infiltrating CD4+ and CD8+ T cells in a GL261 murine glioma model in combination with anti-CD47
Cayman Chemical Capecitabine, Purity: ≥98%, CAS: 154361-50-9, 5 g
A prodrug of 5-fluorouracil; cytotoxic only at high concentrations in Scaber, SIHA, and MKN45 cells (IC50s = 97, 578, and 994 µM, respectively); inactive in a variety of cancer cell lines, including COLO205, HCT116, and MCF-7 cells (IC50s = >1,000 µM)
Sigma Aldrich Fine Chemicals Biosciences Pioglitazone hydrochloride United States Pharmacopeia (USP) Reference Standard | 112529-15-4 | MFCD04975446 | 100MG
Pioglitazone hydrochloride United States Pharmacopeia (USP) Reference Standard | Mol Wt: 392.9 | 112529-15-4 | MFCD04975446 | 100MG
Medchemexpress LLC Berberine hemisulfate | 316-41-6 | 384.40 | 1 G
Berberine hemisulfate is an alkaloid isolated from the Chinese herbal medicine Huanglian. This compound demonstrates anti-inflammatory, antibiobic, antitumor, cardiovascular protective, and neuroprotective activities, and is intended for research use only.
- Exhibits antimicrobial activity by inhibiting cell division protein FtsZ or through DNA/RNA binding.
- Shows anti-inflammatory activity by inhibiting TNF-α and its downstream pathways AP-1 and NF-kB.
- Provides neuroprotective efficacy by inhibiting reactive oxygen species (ROS) production and caspase activation.
- Attenuates metabolic diseases by regulating lipid composition and inhibiting insulin resistance.
Medchemexpress LLC Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) | 25 MG
Amoxicillin (trihydrate) mixture with potassium clavulanate (4:1) is an antibiotic characterized by good oral absorption and broad-spectrum antimicrobial activity. It functions by inhibiting the biosynthesis of polypeptides in the cell wall, thereby hindering cell growth.
- Good oral absorption
- Broad-spectrum antimicrobial activity
- Inhibits biosynthesis of polypeptides in the cell wall
- Inhibits cell growth
- For research use only
Medchemexpress LLC Mifepristone | 84371-65-3 | 99.9% | 429.59 | 1 ML
Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay. It was discovered as the first competitive progesterone antagonist, stimulating a search for more potent and selective antiprogestins.
- Progesterone receptor and glucocorticoid receptor antagonist
- Inhibits cell growth
- Potentiates doxorubicin-induced cytotoxicity in K562/R7 cells
- Reduces severity of EtOH withdrawal in vivo
Sigma Aldrich Fine Chemicals Biosciences Dibenzosuberone European Pharmacopoeia (EP) Reference Standard | 1210-35-1 | MFCD00003587 |
Dibenzosuberone European Pharmacopoeia (EP) Reference Standard | Mol Wt: 208.26 | 1210-35-1 | MFCD00003587 |
Medchemexpress LLC Neriifolin | 466-07-9 | 1 MG
Neriifolin is a CNS-penetrating cardiac glycoside that functions as an inhibitor of Na+, K+-ATPase. It targets beclin 1, inhibiting the formation of LC3-associated phagosomes and ameliorating the development of experimental autoimmune encephalomyelitis (EAE). This compound induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, making it suitable for laboratory research applications.
- CNS-penetrating cardiac glycoside
- Inhibitor of Na+, K+-ATPase
- Targets beclin 1
- Inhibits LC3-associated phagosome formation
- Ameliorates experimental autoimmune encephalomyelitis (EAE) development
- Induces cell cycle arrest and apoptosis in HepG2 cells
- Purity: 99.70%
- Appearance: Solid
- Color: White to yellow
- Molecular weight: 534.68
- Soluble in DMSO (100 mg/mL)
Medchemexpress LLC Methylprednisolone succinate (sodium) | 2375-03-3 | ≥95% | 5 MG
Methylprednisolone succinate sodium is a prodrug of Methylprednisolone and a glucocorticoid with immunosuppressant and anti-inflammatory activity. It binds cytosolic glucocorticoid receptors, translocates to nuclei, and modulates target gene transcription. This compound alters Bax, Bcl-2, occludin, and ZO-1 expression; attenuates TLR4/NF-κB signaling; and suppresses proinflammatory cytokine production and immune cell activation. It can be used for research of intracranial haemorrhage, rheumatoid arthritis, multiple sclerosis, preterminal cancer, inflammatory conditions, shock, immediate-type hypersensitivity, acute myocardial ischemia, hypoxic heart muscle damage, and traumatic spinal cord injury.
- Target: glucocorticoid receptor.
- Research areas: infection, neurological disease, inflammation/immunology, cancer.
- Immunosuppressant and anti-inflammatory activity.
Medchemexpress LLC Naphazoline nitrate | 5144-52-5 | 99.1% | 273.29 | 100 MG
Naphazoline nitrate is an α-adrenergic receptor agonist that reduces vascular hyperpermeability and promotes vasoconstriction. It also reduces levels of inflammatory factors and can be used for non-bacterial conjunctivitis research.
- Targets α-adrenergic receptors
- Helps manage vascular issues
- Decreases levels of TNF-α, IL-1β, IL-6, IFN-γ, IL-4, IgE, GMCSF, and NGF
- Applicable for non-bacterial conjunctivitis research
- Solid, white to off-white appearance
- Solubility: 100 mg/mL in DMSO
Medchemexpress LLC Gemcitabine monophosphate disodium | 1638288-31-9 | 387.14 | 10 MM * 1 ML
Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine. It has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles.
- Active intermediate of Gemcitabine.
- Synergistic anti-cancer effect.
- Can be delivered via nanoparticles.
- In vivo studies show it induces tumor cell apoptosis (30-40%), reduces tumor cell proliferation by 8 times, significantly reduces tumor microvessel density (MVD), and inhibits tumor mitosis in subcutaneous and orthotopic xenograft mouse models of non-small cell lung cancer.
Medchemexpress LLC Ibiglustat (succinate) | 1629063-80-4 | 99.7% | 507.57 | 50 MG
Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant glucosylceramide synthase (GCS) inhibitor. It can be utilized for research related to Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.
- Orally active.
- Brain-penetrant glucosylceramide synthase (GCS) inhibitor.
- Can be used for research of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.